If you go the operator route, you're probably not going to want to change locations unless you're leaving OPS. The reason is, you'll need to go through license class again where ever you end up, as your license is specific to the station.
For the clearance, operators get a DOE-L clearance, which is the equivalent of Secret, it's just a question of who's doing it. I'm pretty sure you'd have to start over, but I could be wrong. The good news is, if you have to start over, you can reuse everything from your other application and the process shouldn't take too long.
Since you're not from that area, you may want to go with the NRC, as it's easier to move around and get to a location you like. Otherwise, look for an OPS position near where you want to live, if that's what you want.